pt. 1. Strategies -- Chemical construction of immunotoxins -- Construction of ribonuclease-antibody conjugates for selective cytotoxicity -- Intracellular targeting using bispecific antibodies -- Antibody conjugation methods for active targeting of liposomes -- Folate as a targeting device for proteins utilizing folate receptor-mediated endocytosis -- Preparation of recombinant RNase single-chain antibody fusion proteins -- pt. 2. Theoretical aspects -- Practical considerations in the exploitation of passive tumor targeting -- Effect of dose, molecular size, and binding affinity on uptake of antibodies -- Inhibition of tumor blood flow -- pt. 3. Applications -- Targeting in myocardial infarction -- Targeting HIV-infected cells -- Making fusion toxins to targetleukemia and lymphoma -- Antibody-bearing liposomes as chloroquine vehicles in treatment of murine malaria -- Immunotargeting of catalase to the pulmonary vascular endothelium -- Targeted gene transfer: a practical guide based on experience with lipid-based plasmid delivery systems
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Access-restricted-item true Addeddate 2020-06-03 03:03:50 Associated-names Francis, G. E; Delgado, Cristina Boxid IA1805221 Camera USB PTP Class Camera Collection_set printdisabled External-identifier urn:lcp:drugtargetingstr0000unse:lcpdf:184650ab-843d-434f-88e0-5fe843395e2e
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